Inventi Rapid: Ethnopharmacology

Inventi:prep/80342/24

To Evaluate the Antiepileptic Activity of Butanolic Extract of Leaves of Butea monosperma against Picrotoxin Induced Convulsion in Mice

Epilepsy is the second most common neurological disorder in India. The prevalence of epilepsy is 0.7% in India. The aim of study was to evaluate the antiepileptic activity of butanolic extract of leaves of Butea monosperma against picrotoxin induced convulsion in mice. Butea monosperma is a small to medium sized tree extensibly used in Ayurveda, Unani and Homeopathic medicine and has become a cynosure of modern medicine. Butea monosperma is used as tonic, astringent, aphrodisiac and diuretics etc. Healthy albino mice weighing 25-30g were used. The animals were grouped containing six in each labeled I - IV. Convulsion was induced by picrotoxin (2mg/kg;p.o.). Time for onset of action (clonic and tonic seizures) and death was recorded. Group I was served as toxic control. Group II will be treated with Diazepam (4mg/kg i.p.) + Picrotoxin (2mg/kg i.p.). Group III and group IV will be treated with Butea monosperma (100mg/kg p.o.) and (200mg/kg p.o.) respectively, half an hour before the treatment of picrotoxin (2mg/kg i.p.). Delay in onset of action and mortality rate of animals will be considered as anticonvulsant property. The results were expressed as mean±SEM and were statistically analyzed by one way ANOVA. It was concluded that butanolic extract of leaves of Butea monosperma showed antiepileptic activity against electroshock convulsions in mice and reduced mortality....